SirT1 brings stemness closer to cancer and aging
نویسندگان
چکیده
Sirtuin 1 acts in various cell processes, deacetylating both chromatin and non-histone proteins, and its role in cancer and aging has long been studied and debated. Here we discuss another aspect of SirT1 biology, its function as a stem cell pluripotency and differentiation regulator. We evaluate the implications of these findings in sirtuin inhibition-based cancer treatment and in the application of sirtuin activation for anti-aging therapy.
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2011